Finally decided to move on
Vista 32bit(for a short period of time) and make some tests with my software...
I was suprised when I tried to run the latest beta of LCD Smartie! I ensure you: there was not a single issue running up to three instances of LCD Smartie.
I have used:

A Matrix Orbilal serial connection using a PCI card serial port (Com 6).

An usb LCD using serial port emulation (Com 3).

And finally,
the part I'm really impressed of, a parallel connection of HD44780 based LCD module.
The next step is to check plugins one by one and report here.
WELCOME VISTA - LONG LIVE TO LCD SMARTIE
